Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Chang CC, Pan S, Chen SH, Liu JD, Lien GS, Lin SY, Jeng YS, Suk FM, Lin SH, Shu YS, Chen JN, Wu MS, Chen YF
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------>journal_name=Gastroenterol J Taiwan
------>paper_name=The Relationship Between Duodenal Ulcer and Superoxide Dismutase
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------>fullAbstract=Repeated administration of diethyldithiocarbamate (DDC: 750 mg/kg, s.c.), a superoxide dismutase (SOD) inhibitor, to fed rats induced ulcers in the duodenum with less lesion in the stomach. DDC not only reduced basal acid output but also impaired duodenal alkaline secretion under both basal and acid-stimulated conditions. The duodenal ulcers induced by DDC were significantly prevented by either allopurinol, SOD or dmPGE2 at the doses which significantly reversed the inhibited alkaline responses caused by DDC. The pathogenesis of DDC-induced duodenal ulcers may involve impairment of duodenal alkaline secretion, probably caused by insufficiency of antioxidant machinery in the mucosa.
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------>authors=Chang CC, Pan S, Chen SH, Liu JD, Lien GS, Lin SY, Jeng YS, Suk FM, Lin SH, Shu YS, Chen JN, Wu MS, Chen YF
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------>updateTitle=A new model of duodenal ulcers induced in rats by diethyldithiocarbamate, a superoxide dismutase inhibitor.
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------>publish_year=1998
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z