| Ju-Chi Liu, Paul Chan, Yi-Jen Chen, Brian Tomlinson, Sheu-Fang Hong, Juei-Tang Cheng. |
------>authors3_c=None ------>paper_class1=1 ------>Impact_Factor=None ------>paper_class3=2 ------>paper_class2=1 ------>vol=59 ------>confirm_bywho=span ------>insert_bywho=ahom ------>Jurnal_Rank=None ------>authors4_c=None ------>comm_author= ------>patent_EDate=None ------>authors5_c=None ------>publish_day=None ------>paper_class2Letter=None ------>page2=289 ------>medlineContent= ------>unit=E0109 ------>insert_date=20010425 ------>iam=1 ------>update_date= ------>author=??? ------>change_event=5 ------>ISSN=None ------>authors_c=None ------>score=500 ------>journal_name=Pharmacology ------>paper_name=The antihypertensive effect of the berberine derivative 6-protoberberine in spontaneously hypertensive rats. ------>confirm_date=20010522 ------>tch_id=089006 ------>pmid=10575322 ------>page1=283 ------>fullAbstract=Berberine is a natural isoquinoline alkaloid found in plants of the Ranunculaceae and Berberidaceae families. Extracts from berberine-containing plants have been used as traditional Chinese folk remedies for centuries. The antihypertensive effects of the berberine derivative 6-protoberberine (PTB-6) were studied in spontaneously hypertensive rats (SHRs). In conscious SHRs, PTB-6 lowered the systolic blood pressure in a dose-dependent manner (6-PTB: 5 mg/kg, -31.1 +/- 1.6 mm Hg; 10 mg/kg, -42.4 +/- 3.1 mm Hg). Cardiac output using the thermodilution method was reduced in PTB-6-treated anesthetized SHRs with a tendency to decrease in heart rate. Injection of PTB-6 into the intracerebral ventricles of SHRs lowered the systolic arterial blood pressure and heart rate. The berberine derivative PTB-6 is an effective antihypertensive agent. The mechanism of the antihypertensive effect of PTB-6 is probably through a central sympatholytic effect. Copyright Copyright 1999 S. Karger AG, Basel ------>tmu_sno=None ------>sno=3679 ------>authors2=None ------>authors3=None ------>authors4=None ------>authors5=None ------>authors6=None ------>authors6_c=None ------>authors=Ju-Chi Liu, Paul Chan, Yi-Jen Chen, Brian Tomlinson, Sheu-Fang Hong, Juei-Tang Cheng. ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=None ------>publish_area=None ------>updateTitle=The antihypertensive effect of the berberine derivative 6-protoberberine in spontaneously hypertensive rats. ------>language=2 ------>check_flag= ------>submit_date= ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho= ------>publish_year=1999 ------>submit_flag= ------>publish_month=None |