| Matsuo, K., Taniyama, K., Kaibara, M., Uezono, Y., Tsai, L.H., and Hawakami, S. |
------>authors3_c=None ------>paper_class1=2 ------>Impact_Factor=None ------>paper_class3=0 ------>paper_class2=0 ------>vol=85 ------>confirm_bywho=wslee ------>insert_bywho=lhtsai ------>Jurnal_Rank=None ------>authors4_c=None ------>comm_author= ------>patent_EDate=None ------>authors5_c=None ------>publish_day=None ------>paper_class2Letter=None ------>page2=113 ------>medlineContent= ------>unit=E0105 ------>insert_date=20010425 ------>iam=5 ------>update_date= ------>author=??? ------>change_event=5 ------>ISSN=None ------>authors_c=None ------>score=160 ------>journal_name=The Japanese Journal of Pharmacology ------>paper_name=Mechanism underlying orexin-induced contraction of guinea pig intestine. ------>confirm_date=20010426 ------>tch_id=059001 ------>pmid=12323391 ------>page1=113 ------>fullAbstract=The mechanism underlying orexin-induced contraction was examined in isolated preparations of guinea pig ileum, in relation to cholinergic transmission. Orexin-A caused contraction of ileal strips in a concentration-dependent manner. 1-(2-Methylbenzoxazol-6-yl)-3-[1,5]napthyridin-4-yl-urea hydrochloride (SB-334867-A) antagonized the orexin-A-induced contraction, with no effects on the acetylcholine-induced contraction and twitch contractions. The orexin-A-induced contraction was inhibited by tetrodotoxin and atropine, but not by hexamethonium, an antagonist of vasoactive intestinal peptide and a mixture of 5-hydroxytryptamine receptor antagonists. Orexin-A evoked an outflow of [3H]acetylcholine from the ileal strips preincubated with [3H]choline, in a concentration-dependent manner, and the orexin-A-evoked outflow was inhibited by tetrodotoxin, indicating that the outflow of [3H]acetylcholine originates from the nerve terminals. The orexin-A-evoked outflow of [3H]acetylcholine was antagonized by SB-334867-A. Thus, orexin-A evokes the release of acetylcholine from the enteric cholinergic neurons due to stimulation of the orexin-1 receptors and then causes contractions of guinea pig ileum. ------>tmu_sno=None ------>sno=3683 ------>authors2=None ------>authors3=None ------>authors4=None ------>authors5=None ------>authors6=None ------>authors6_c=None ------>authors=Matsuo, K., Taniyama, K., Kaibara, M., Uezono, Y., Tsai, L.H., and Hawakami, S. ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=None ------>publish_area=None ------>updateTitle=Involvement of cholinergic neurons in orexin-induced contraction of guinea pig ileum. ------>language=2 ------>check_flag= ------>submit_date= ------>country=None ------>no=S-I ------>patent_SDate=None ------>update_bywho= ------>publish_year=2001 ------>submit_flag= ------>publish_month=None |