Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Ko WC, Sheu JR, Leu YR, Tzeng SH and Chen CM
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------>journal_name=J. Pharm. Pharmacol.
------>paper_name=Stereoselectivity of butyidenephthalide on voltage-dependent calcium channels in guinea-pig isolated ileum.
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------>fullAbstract=Two geometric isomers, the Z- and the E- forms, can be separated from synthetic mixtures of butylidenephthalide (Bdph). Z-Bdph (50-100 microM) non-competitively inhibited Ca(2+)-induced contractions in depolarized (K+, 60 mM) guinea-pig ileum longitudinal smooth muscle, with a pD2~ value of 3.88 +/- 0.20 (n = 5). However, E-Bdph (20-100 microM) competitively inhibited these contractions with a pA2 value of 4.56 +/- 0.18 (n = 5) which was significantly (P < 0.05) greater than the pD2~ value of Z-Bdph. In contrast, the two isomers had no stereoselective inhibitory action on Ca2+ influx through pre- or post-junctional membranes of cholinergic nerve endings from which the transmitter acetylcholine is released or on Ca2+ release from intracellular stores. Therefore, the trans-Z and cis-E forms of Bdph might have geometric stereoselectivity for voltage-dependent calcium channels (VDC) in guinea-pig longitudinal smooth muscle. Both isomers might inhibit more selectively the contractile twitch responses evoked by electrical stimulation than by cumulative acetylcholine- or carbachol-induced transient contractions in guinea-pig ileum longitudinal smooth muscle.
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------>authors=Ko WC, Sheu JR, Leu YR, Tzeng SH and Chen CM
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------>updateTitle=Stereoselectivity of butylidenephthalide on voltage-dependent calcium channels in guinea-pig isolated ileum.
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------>publish_year=1997
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z