| George Hsiao, Yun-Ho Lin, Chien-Huang Lin, Duen-Suey Chou and Joen-Rong Sheu. |
------>authors3_c=None ------>paper_class1=1 ------>Impact_Factor=None ------>paper_class3=2 ------>paper_class2=1 ------>vol=24 ------>confirm_bywho=sheujr ------>insert_bywho=fird ------>Jurnal_Rank=None ------>authors4_c=None ------>comm_author= ------>patent_EDate=None ------>authors5_c=None ------>publish_day=None ------>paper_class2Letter=None ------>page2=1276 ------>medlineContent= ------>unit=E0106 ------>insert_date=20011015 ------>iam=4 ------>update_date= ------>author=??? ------>change_event=4 ------>ISSN=None ------>authors_c=None ------>score=484 ------>journal_name=Biological Pharmaceutical Bulletin ------>paper_name=The protective effects of PMC against chronic carbon tetrachlori-induced hepatotoxicity in vivo ------>confirm_date=20050412 ------>tch_id=074004 ------>pmid=11725962 ------>page1=1271 ------>fullAbstract=In this study, PMC (2,2,5,7,8-pentamethyl-6-hydroxychromane), a derivative of alpha-tocopherol, dose-dependently (1-10 mg/kg) ameliorated the increase in plasma aspartate aminotransferase (GOT) and alanine aminotransferase (GPT) levels caused by chronic repeated carbon tetrachloride (CCl4) intoxication in mice. Moreover, PMC significantly improved the CCl4-induced increase of hepatic glutathione peroxidase, reductase, and superoxide dismutase activities. PMC also restored the decrement in the glutathione content of hepatic tissues in CCl4-intoxicated mice. Furthermore, it also dose-dependently inhibited the formation of lipid peroxidative products during carbon tetrachloride treatment. Histopathological changes of hepatic lesions induced by carbon tetrachloride were significantly improved by treatment with PMC in a dose-dependent manner. These results suggest that PMC exerts effective protection in chronic chemical-induced hepatic injury in vivo. ------>tmu_sno=None ------>sno=4326 ------>authors2= ------>authors3= ------>authors4= ------>authors5= ------>authors6= ------>authors6_c=None ------>authors=George Hsiao, Yun-Ho Lin, Chien-Huang Lin, Duen-Suey Chou and Joen-Rong Sheu. ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=None ------>publish_area=None ------>updateTitle=The protective effects of PMC against chronic carbon tetrachloride-induced hepatotoxicity in vivo. ------>language=2 ------>check_flag= ------>submit_date= ------>country=None ------>no=11 ------>patent_SDate=None ------>update_bywho= ------>publish_year=2001 ------>submit_flag= ------>publish_month=None |