Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Hsu FL, Hou CC, Yang LM, Cheng JT, Chi TC, Liu PC, and Lin SJ
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------>journal_name=J. Nat. Prod.
------>paper_name=Microbial Transformations of Isosteviol
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------>fullAbstract=Microbial transformations of the tetracyclic diterpenoid isosteviol (ent-16-ketobeyeran-19-oic acid) (2) have revealed that isosteviol is metabolized by Cunninghamella bainieri, Actinoplanes sp., Mucor recurvatus, and Cunninghamella blakesleeana to yield five new metabolites, ent-11alpha,12alpha-dihydroxy-16-ketobeyeran-19-oic acid (5), ent-11alpha,12alpha,17-trihydroxy-16-ketobeyeran-19-oic acid (6), ent-12alpha,15alpha-dihydroxy-16-ketobeyeran-19-oic acid (7), ent-7alpha,15alpha-dihydroxy-16- ketobeyeran-19-oic acid (8), and ent-9alpha-hydroxy-16-ketobeyeran-19-oic acid (9), together with three known metabolites, ent-7alpha-hydroxy-16-ketobeyeran-19-oic acid (3), ent-7beta-hydroxy-16-ketobeyeran-19-oic acid (4), and ent-12alpha-hydroxy-16-ketobeyeran-19-oic acid (10). The structures of these metabolites were established on the basis of HRFABMS and 1D and 2D NMR spectral data. In addition, metabolites 3-10 were tested for antihypertensive activity and were found to be less active than the parent compound 2.
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------>authors=Hsu FL, Hou CC, Yang LM, Cheng JT, Chi TC, Liu PC, and Lin SJ
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------>updateTitle=Microbial transformations of isosteviol.
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------>publish_year=2002
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z