| Naruishi K, Takashiba S, Nishimura F, Chou HH, Arai H, Yamada H, Murayama Y. |
------>authors3_c=None ------>paper_class1=1 ------>Impact_Factor=3.131 ------>paper_class3=2 ------>paper_class2=1 ------>vol=80 ------>confirm_bywho=seanlee ------>insert_bywho=hhchou ------>Jurnal_Rank=4.2 ------>authors4_c=None ------>comm_author= ------>patent_EDate=None ------>authors5_c=None ------>publish_day=1 ------>paper_class2Letter=None ------>page2=1424 ------>medlineContent= ------>unit=F0100 ------>insert_date=20020327 ------>iam=3 ------>update_date= ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c=None ------>score=500 ------>journal_name=J Dent Res. ------>paper_name=Impairment of gingival fibroblast adherence by IL-6/sIL-6R. ------>confirm_date=20060213 ------>tch_id=086008 ------>pmid=11437212 ------>page1=1421 ------>fullAbstract=Interleukin-6 (IL-6) binds to human gingival fibroblasts (HGF) in the presence of a soluble form of IL-6 receptor (sIL-6R). We investigated the effects of IL-6 on the functions of HGF in the presence of sIL-6R. HGF changed their morphology from spindle-shaped to round, and detached from the culture dish by stimulation with IL-6/sIL-6R. In this condition, a signal transducer gp130 and a transcription factor Stat3 were phosphorylated, resulting in activation of transcription factors Stat3 and C/EBPbeta. Cytoskeletal beta-actin and adhesion molecule integrin-alpha5, a subunit of alpha5beta1 integrin (VLA-5), were found to possess potential binding domains for these transcription factors in their promoters. Accumulation of beta-actin and integrin-alpha5 mRNA decreased, contrary to the expectation of the induction of gene transcription. Furthermore, the decrease in their mRNAs was associated with reduced expression of both actin and VLA-5 proteins. These results suggest that the expression of VLA-5 and actin was down-regulated in HGF through an IL-6 signaling pathway, resulting in impairment of HGF adherence. ------>tmu_sno=None ------>sno=5128 ------>authors2= ------>authors3= ------>authors4= ------>authors5= ------>authors6= ------>authors6_c=None ------>authors=Naruishi K, Takashiba S, Nishimura F, Chou HH, Arai H, Yamada H, Murayama Y. ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=None ------>publish_area=0 ------>updateTitle=Impairment of gingival fibroblast adherence by IL-6/sIL-6R. ------>language=2 ------>check_flag= ------>submit_date= ------>country=None ------>no=5 ------>patent_SDate=None ------>update_bywho= ------>publish_year=2001 ------>submit_flag= ------>publish_month=1 |