Taipei Medical University

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Ko WC, Yang JY and Chen CM
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------>journal_name=J. Chromatogr. B
------>paper_name=Determination of Z-butylidenephthalide in plasma by high-performance liquid chromatography.
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------>fullAbstract=An HPLC assay is described for the determination of Z-butylidenephthalide (Z-Bdph) in plasma. Plasma samples were cleaned up by extraction with 2% chloroform in n-hexane. Z-Bdph was separated on a normal-phase silica column with a mobile phase of chloroform-n-hexane (1:1). The limit of quantitation with UV detection at 254 nm for Z-Bdph in plasma was 0.01 microgram/ml. The recovery of Z-Bdph by organic solvent extraction of plasma was 99.5%. The intra-day and inter-day coefficients of variation and relative errors for Z-Bdph determination in plasma were both less than 10%. The present method was applied to pharmacokinetic studies of Z-Bdph in plasma after intravenous administration to rabbits.
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------>authors=Ko WC, Yang JY and Chen CM
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------>updateTitle=Determination of Z-butylidenephthalide in plasma by high-performance liquid chromatography.
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------>publish_year=1996
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z