| Lee T H, Wang G J, Lee C K, Lee Y H, Kuo Y H, Chou C H |
------>authors3_c=None ------>paper_class1=1 ------>Impact_Factor=None ------>paper_class3=2 ------>paper_class2=1 ------>vol=68 ------>confirm_bywho=kyhsu ------>insert_bywho=cklee ------>Jurnal_Rank=None ------>authors4_c=None ------>comm_author= ------>patent_EDate=None ------>authors5_c=None ------>publish_day=None ------>paper_class2Letter=None ------>page2=496 ------>medlineContent= ------>unit=000 ------>insert_date=20030320 ------>iam=3 ------>update_date= ------>author=??? ------>change_event=5 ------>ISSN=None ------>authors_c=None ------>score=460 ------>journal_name=Planta Med ------>paper_name=In Inhibitoty effects of Glycosides from the Leaves of Melaleuca quinquenervia on Vascular Contraction of rats ------>confirm_date=20030321 ------>tch_id=091116 ------>pmid=12094289 ------>page1=492 ------>fullAbstract=Two new glycosides, 3-hydroxy-5-methoxy-4-methylphenyl beta-D-glucopyranoside (1) and 4-benzoyl-2-C-beta-glucopyranosyl-3,5-dihydroxy-6-methylphenyl beta-D-glucopyranoside (2), together with four known glycosides, 2-endo-beta-D-glucopyranosyloxy-1,8-cineole (3a), 2-exo-beta-D-glucopyranosyloxy-1,8-cineole (3b), roseoside (4), and citroside A (5), were isolated from the methanolic extract of leaves of Melaleuca quinquenervia. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 1, 2a and 3 inhibited contractile response induced by phenylephrine in aortic rings from Sprague-Dawley rats. This inhibition was independent of the endothelium. Compounds 2 and 4 significantly relaxed precontracted aortic rings, in an endothelium-dependent manner. Pretreatment of N(omega)-nitro-L-arginine (L-NNA), a nitric oxide synthase inhibitor, partially attenuated the vasorelaxation induced by both compounds, suggesting that nitric oxide was likely the responsible mediator. The rank-order potency (EC 50 value) of vasorelaxing activities of these compounds is 4 > 2 > 2a > 3 > 1. ------>tmu_sno=None ------>sno=6485 ------>authors2=None ------>authors3=None ------>authors4=None ------>authors5=None ------>authors6=None ------>authors6_c=None ------>authors=Lee T H, Wang G J, Lee C K, Lee Y H, Kuo Y H, Chou C H ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=None ------>publish_area=None ------>updateTitle=Inhibitory effects of glycosides from the leaves of Melaleuca quinquenervia on vascular contraction of rats. ------>language=2 ------>check_flag= ------>submit_date= ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho= ------>publish_year=2002 ------>submit_flag= ------>publish_month=None |