Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Lee LM
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------>journal_name=Anticancer Research
------>paper_name=Expression of Cyclooxygenase-2 in Prostate Adenocarcinoma and Benign Prostatic Hyperplasia
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------>fullAbstract=Elevated expression of cyclo-oxygenase (COX)-2 has been found in several human cancers, including prostate adenocarcinoma. To evaluate the potential prognostic role of COX-2 in prostate cancer, we assessed the expression of COX-2 in benign prostatic hyperplasia (BPH) and prostate cancer samples employing immunohistochemistry. COX-2 was over-expressed in 15 out of 18 (83%) prostate cancer samples whereas it was detected in only 22% (4 of 18) paired benign tissues. The intensity of immunostaining correlated with the tumor grading. In addition, COX-2 was expressed in 7 of the 22 (32%) BPH samples examined. The significance a COX-2 expression in the BPH samples is not known at present. This data suggest that COX-2 is over-expressed in prostate cancer and COX-2 inhibitors may be useful in combination chemotherapy or chemoprevention for prostate cancer.
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------>authors=Lee LM
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------>updateTitle=Expression of cyclooxygenase-2 in prostate adenocarcinoma and benign prostatic hyperplasia.
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------>publish_year=2001
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z