| Zhao HL, Thomas GN, Leung W YS, Tomlinson B, Hsieh MH, Chan P |
------>authors3_c=None ------>paper_class1=1 ------>Impact_Factor=None ------>paper_class3=1 ------>paper_class2=3 ------>vol=19 ------>confirm_bywho=tlc ------>insert_bywho=chanpaul ------>Jurnal_Rank=None ------>authors4_c=None ------>comm_author=1 ------>patent_EDate=None ------>authors5_c=None ------>publish_day=None ------>paper_class2Letter=None ------>page2=11 ------>medlineContent= ------>unit=E0100 ------>insert_date=20030916 ------>iam=7 ------>update_date= ------>author=??? ------>change_event=5 ------>ISSN=None ------>authors_c=None ------>score=-81 ------>journal_name=Acta Cardiol Sin ------>paper_name=Statins in Lipid-lowering Therapy ------>confirm_date=20031018 ------>tch_id=086019 ------>pmid=19911349 ------>page1=1 ------>fullAbstract=BACKGROUND: Recent studies have demonstrated that statins may possess antiarrhythmic properties in addition to their lipid-lowering effects. METHODS: Studies which reported the association of statins with the incidence of atrial arrhythmias were identified through a systematic review of published literature. RESULTS: One randomized, placebo-controlled trial of 200 patients undergoing cardiac surgery showed that atorvastatin decreased the incidence of postoperative atrial fibrillation by 61%. Observational studies in patients with stable coronary disease, left ventricular dysfunction, or those undergoing cardiac or noncardiac surgery show that statin therapy is associated with an approximately 50% lower rate of atrial fibrillation. Two small randomized trials reported conflicting results: one showing that atorvastatin reduced the recurrence of AF after electrical cardioversion and the other finding that pravastatin did not. CONCLUSIONS: Published data suggests that statins may possess antiarrhythmic properties that reduce the propensity for atrial fibrillation. Most of this data is observational; more randomized, placebo-controlled trials are needed. Copyright (c) 2009 Wiley Periodicals, Inc. ------>tmu_sno=None ------>sno=7552 ------>authors2=None ------>authors3=None ------>authors4=None ------>authors5=None ------>authors6=None ------>authors6_c=None ------>authors=Zhao HL, Thomas GN, Leung W YS, Tomlinson B, Hsieh MH, Chan P ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=None ------>publish_area=None ------>updateTitle=Statins as Antiarrhythmics: A Systematic Review Part I: Effects on Risk of Atrial Fibrillation. ------>language=1 ------>check_flag= ------>submit_date= ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho= ------>publish_year=2003 ------>submit_flag= ------>publish_month=None |