| Lu HK |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=2.497 ------>paper_class3=2 ------>paper_class2=1 ------>vol=68B ------>confirm_bywho=seanlee ------>insert_bywho=jackson ------>Jurnal_Rank=21.4 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=80 ------>medlineContent= ------>unit=F0100 ------>insert_date=20031017 ------>iam=1 ------>update_date= ------>author=??堃 ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=J Biomed Mater Res ------>paper_name=Comparison of Th1/Th2 cytokine profiles of initial wound healing of rats induced by PDCM and e-PTFE ------>confirm_date=20070810 ------>tch_id=076001 ------>pmid=14689499 ------>page1=75 ------>fullAbstract=Because periodontal regeneration is vital in the modern treatment of periodontal defects, artificial membranes have become a key component for predictable outcomes. Herein a new ranking system to analyze the expression of different cytokines around regenerative membranes is introduced. Porcine dermal collagen membranes (PDCMs) and GORE-TEX (e-PTFE) membranes were used for implantation in a Sprague Dawley rat model. Tissue samples were harvested at three time intervals (7, 10, and 14 days); then an immunohistochemical ranking process was conducted to determine the intensity of the selected Th1/Th2 cytokines [Th1: interleukin-2 (IL-2) and interferone-gamma (IFN-gamma); Th2: IL-4, IL-10, and IL-13]. The results show that the intensities of IL-2 cytokine in PDCM groups were slightly higher than those of e-PTFE groups but without statistical significance. The level of interferon-gamma in PDCM groups was lower than that of e-PTFE groups, but also without significant differences. However, expressions of Th2 cytokines (IL-4, IL-10, and IL-13) induced by e-PTFE were generally higher than those of PDCM and control groups at all times (Mann-Whitney U test, p < 0.05). In a comparison of the mean ratio of IL-2/IL-4 with the use of the Mann-Whitney U test, data for the PDCM group were generally higher than those of the e-PTFE group, with statistical significance at all time intervals (p < 0.05). A descending order of the intensity ratio of IL-2/IL-4 was PDCM groups > control groups > e-PTFE groups. These findings indicate that the cytokine profiles of PDCM, in connection with the GTR technique, demonstrate a higher trend toward Th1-dominated responses and may protect against periodontal tissue destruction, as compared to the Th2-dominated responses of e-PTFE. ------>tmu_sno=None ------>sno=7853 ------>authors2=Ko MT ------>authors3=Wu MF ------>authors4= ------>authors5= ------>authors6= ------>authors6_c= ------>authors=Lu HK ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Comparison of Th1/Th2 cytokine profiles of initial wound healing of rats induced by PDCM and e-PTFE. ------>language=2 ------>check_flag= ------>submit_date= ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho= ------>publish_year=2004 ------>submit_flag= ------>publish_month=1 |