| Jin-Yuan Shih, Yuan-Chii G. Lee, Shuenn-Chen Yang, Tse-Ming Hong, CShih JY, Lee YCG, Yang SC, Hong TM, Huang CYF and Yang PC |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=3.048 ------>paper_class3=2 ------>paper_class2=3 ------>vol=20 ------>confirm_bywho=cyhsu ------>insert_bywho=ycgl ------>Jurnal_Rank=36.6 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=74 ------>medlineContent= ------>unit=E0700 ------>insert_date=20031023 ------>iam=2 ------>update_date= ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Clinical and Experimental Metastasis ------>paper_name=Collapsin Response Mediator Protein-1: A Novel Invasion-Suppressor Gene ------>confirm_date=20061220 ------>tch_id=092072 ------>pmid=12650609 ------>page1=69 ------>fullAbstract=Numerous genetic changes are associated with metastasis of cancer cells. Previously, we used microarray to identify that collapsin response mediator protein-1 (CRMP-1) was involved in cancer invasion and metastasis. We further characterized that CRMP-1 was a novel invasion-suppression gene. Members of the CRMP gene family are intracellular phosphoproteins involved in the mediation of semaphorin induced F-actin depolymerization and growth cone collapse. The precise mechanism by which CRMP-I inhibits invasion is not yet clear. However, CRMP-1 transfected cells had fewer filopodia and less Matrigel-invasion abilities. A low expression of CRMP-I mRNA in lung cancer tissue was significantly associated with advanced disease, lymph node metastasis, early post-operative relapse, and shorter survival. In this article, we reviewed the functions of CRMPs and semaphorins and analyzed the structure and motifs of CRMP-1 by bioinformatics. As such, we hoped to shed further light on the mechanism by which CRMP-1 suppresses the invasion of cancer cells. ------>tmu_sno=None ------>sno=7997 ------>authors2= ------>authors3= ------>authors4= ------>authors5= ------>authors6= ------>authors6_c= ------>authors=Jin-Yuan Shih, Yuan-Chii G. Lee, Shuenn-Chen Yang, Tse-Ming Hong, CShih JY, Lee YCG, Yang SC, Hong TM, Huang CYF and Yang PC ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Collapsin response mediator protein-1: a novel invasion-suppressor gene. ------>language=2 ------>check_flag= ------>submit_date= ------>country=None ------>no=1 ------>patent_SDate=None ------>update_bywho= ------>publish_year=2003 ------>submit_flag= ------>publish_month=1 |