| Tsou AP, Yang CW, Huang CYF, Yu CTR, Lee YCG, Chang CW, Chen BR, Chung YF, Fann MJ, Chi CW, Chiu JH and Chou CK |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=6.318 ------>paper_class3=2 ------>paper_class2=1 ------>vol=22 ------>confirm_bywho=jack ------>insert_bywho=ycgl ------>Jurnal_Rank=8.9 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=307 ------>medlineContent= ------>unit=E0700 ------>insert_date=20031023 ------>iam=5 ------>update_date= ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Oncogene ------>paper_name=Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma ------>confirm_date=20060505 ------>tch_id=092072 ------>pmid=12527899 ------>page1=298 ------>fullAbstract=An analytic strategy was followed to identify putative regulatory genes during the development of human hepatocellular carcinoma (HCC). This strategy employed a bioinformatics analysis that used a database search to identify genes, which are differentially expressed in human HCC and are also under cell cycle regulation. A novel cell cycle regulated gene (HURP) that is overexpressed in HCC was identified. Full-length cDNAs encoding the human and mouse HURP genes were isolated. They share 72 and 61% identity at the nucleotide level and amino-acid level, respectively. Endogenous levels of HURP mRNA were found to be tightly regulated during cell cycle progression as illustrated by its elevated expression in the G(2)/M phase of synchronized HeLa cells and in regenerating mouse liver after partial hepatectomy. Immunofluorescence studies revealed that hepatoma up-regulated protein (HURP) localizes to the spindle poles during mitosis. Overexpression of HURP in 293T cells resulted in an enhanced cell growth at low serum levels and at polyhema-based, anchorage-independent growth assay. Taken together, these results strongly suggest that HURP is a potential novel cell cycle regulator that may play a role in the carcinogenesis of human cancer cells. ------>tmu_sno=None ------>sno=7999 ------>authors2= ------>authors3= ------>authors4= ------>authors5= ------>authors6= ------>authors6_c= ------>authors=Tsou AP, Yang CW, Huang CYF, Yu CTR, Lee YCG, Chang CW, Chen BR, Chung YF, Fann MJ, Chi CW, Chiu JH and Chou CK ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma. ------>language=2 ------>check_flag= ------>submit_date= ------>country=None ------>no=2 ------>patent_SDate=None ------>update_bywho= ------>publish_year=2003 ------>submit_flag= ------>publish_month=1 |