| Wang CC |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=3.398 ------>paper_class3=2 ------>paper_class2=1 ------>vol=140 ------>confirm_bywho=amel ------>insert_bywho=??? ------>Jurnal_Rank=37.1 ------>authors4_c= ------>comm_author=1 ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=200 ------>medlineContent= ------>unit=G0200 ------>insert_date=19991209 ------>iam=3 ------>update_date= ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Cancer Lett. ------>paper_name=Antitumor activity of four macrocyclic ellagitannins from Cuphea hyssopifolia ------>confirm_date=20081217 ------>tch_id=058001 ------>pmid=10403559 ------>page1=195 ------>fullAbstract=We evaluated the antitumor activities of four macrocyclic hydrolyzable tannin dimers, cuphiin D1, cuphiin D2, oenothein B and woodfordin C isolated from Cuphea hyssopifolia (Lythraceae). All significantly inhibited the growth of the human carcinoma cell lines KB, HeLa, DU-145, Hep 3B, and the leukemia cell line HL-60, and showed less cytotoxicity than adriamycin against a normal cell line (WISH). All four compounds inhibited the viability of S-180 tumor cells in an in vitro assay and an in vivo S-180 tumor-bearing ICR mice model. Oenothein B demonstrated the greatest cytotoxicity (IC50 = 11.4 microg/ml) against S-180 tumor cells in culture, while cuphiin D1 resulted in the greatest increase in survival on S-180 tumor-bearing mice (%ILS = 84.1%). Our findings suggest that the antitumor effects of these compounds are not only related to their cytotoxicity on carcinoma cell lines, but also depended on a host-mediated mechanism; they may therefore have potential for antitumor applications. ------>tmu_sno=None ------>sno=870 ------>authors2=Chen LG ------>authors3=Yang LL ------>authors4= ------>authors5= ------>authors6= ------>authors6_c= ------>authors=Wang CC ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Antitumor activity of four macrocyclic ellagitannins from Cuphea hyssopifolia. ------>language=2 ------>check_flag=0 ------>submit_date= ------>country=None ------>no=1-2 ------>patent_SDate=None ------>update_bywho= ------>publish_year=1999 ------>submit_flag= ------>publish_month=6 |