Cheng TH |
------>authors3_c=None ------>paper_class1=1 ------>Impact_Factor=None ------>paper_class3=2 ------>paper_class2=1 ------>vol=369 ------>confirm_bywho=ncchang ------>insert_bywho=thcheng ------>Jurnal_Rank=None ------>authors4_c=None ------>comm_author= ------>patent_EDate=None ------>authors5_c=None ------>publish_day=None ------>paper_class2Letter=None ------>page2=244 ------>medlineContent= ------>unit=E0109 ------>insert_date=20040506 ------>iam=1 ------>update_date=None ------>author=??? ------>change_event=5 ------>ISSN=None ------>authors_c=None ------>score=500 ------>journal_name=Naunyn-Schmiedeberg's Archives of Pharmacology ------>paper_name=Inhibitory effect of resveratrol on angiotensin II-induced cardiomyocyte hypertrophy. ------>confirm_date=20040507 ------>tch_id=092006 ------>pmid=14663554 ------>page1=239 ------>fullAbstract=Resveratrol is proposed to account in part for the protective effect of red wine on the cardiovascular system. Angiotensin II (Ang II) is a potent hypertrophic stimulus in cardiomyocytes. In this study, we determined the effect of resveratrol on Ang II-induced cardiomyocyte hypertrophy. Cultured neonatal rat cardiomyocytes were stimulated with Ang II, and [3H]leucine incorporation and beta-myosin heavy chain (beta-MyHC) promoter activity were examined. Intracellular reactive oxygen species (ROS) were measured by a redox-sensitive fluorescent dye, 2~ 7~-dichlorofluorescin diacetate, and the extracellular signal-regulated kinase (ERK) phosphorylation was examined by Western blotting. Resveratrol inhibited Ang II-increased intracellular ROS levels. Furthermore, resveratrol, as well as the antioxidant N-acetyl-cysteine, decreased Ang II- or H2O2-increased protein synthesis, beta-MyHC promoter activity, and ERK phosphorylation. In summary, we demonstrate for the first time that resveratrol inhibits Ang II-induced cardiomyocyte hypertrophy via attenuation of ROS generation. ------>tmu_sno=None ------>sno=9047 ------>authors2=Liu JC ------>authors3=Lin H ------>authors4=Shih NL ------>authors5=Chen YL ------>authors6=Huang MT, Chan P, Cheng CF, Chen JJ ------>authors6_c=None ------>authors=Cheng TH ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=None ------>publish_area=None ------>updateTitle=Inhibitory effect of resveratrol on angiotensin II-induced cardiomyocyte hypertrophy. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2004 ------>submit_flag=None ------>publish_month=None |