Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Cheng TH
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------>journal_name=Naunyn-Schmiedeberg's Archives of Pharmacology
------>paper_name=Inhibitory effect of resveratrol on angiotensin II-induced cardiomyocyte hypertrophy.
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------>pmid=14663554
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------>fullAbstract=Resveratrol is proposed to account in part for the protective effect of red wine on the cardiovascular system. Angiotensin II (Ang II) is a potent hypertrophic stimulus in cardiomyocytes. In this study, we determined the effect of resveratrol on Ang II-induced cardiomyocyte hypertrophy. Cultured neonatal rat cardiomyocytes were stimulated with Ang II, and [3H]leucine incorporation and beta-myosin heavy chain (beta-MyHC) promoter activity were examined. Intracellular reactive oxygen species (ROS) were measured by a redox-sensitive fluorescent dye, 2~ 7~-dichlorofluorescin diacetate, and the extracellular signal-regulated kinase (ERK) phosphorylation was examined by Western blotting. Resveratrol inhibited Ang II-increased intracellular ROS levels. Furthermore, resveratrol, as well as the antioxidant N-acetyl-cysteine, decreased Ang II- or H2O2-increased protein synthesis, beta-MyHC promoter activity, and ERK phosphorylation. In summary, we demonstrate for the first time that resveratrol inhibits Ang II-induced cardiomyocyte hypertrophy via attenuation of ROS generation.
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------>authors2=Liu JC
------>authors3=Lin H
------>authors4=Shih NL
------>authors5=Chen YL
------>authors6=Huang MT, Chan P, Cheng CF, Chen JJ
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------>authors=Cheng TH
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------>updateTitle=Inhibitory effect of resveratrol on angiotensin II-induced cardiomyocyte hypertrophy.
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------>publish_year=2004
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z