| Juan SH |
------>authors3_c=None ------>paper_class1=1 ------>Impact_Factor=1.789 ------>paper_class3=2 ------>paper_class2=1 ------>vol=1042 ------>confirm_bywho=leehorng ------>insert_bywho=cmbhhm ------>Jurnal_Rank=15.6 ------>authors4_c=None ------>comm_author=1 ------>patent_EDate=None ------>authors5_c=None ------>publish_day=None ------>paper_class2Letter=None ------>page2=487 ------>medlineContent= ------>unit=E0600 ------>insert_date=20040506 ------>iam=4 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN=None ------>authors_c=None ------>score=452 ------>journal_name=Ann. N.Y. Acad Sci. ------>paper_name=IL-5 inhibits apoptosis by up-regulation of c-myc expression in human hematopoietic cells ------>confirm_date=20060307 ------>tch_id=089027 ------>pmid=15965094 ------>page1=481 ------>fullAbstract=Interleukin 5 (IL-5) inhibition of apoptosis is required throughout many hematopoietic lineages to regulate proliferation and differentiation. It is not clear how IL-5 mediates the intracellular molecular events regulating the anti-apoptotic effect. The cell lines TF-1 and JYTF-1 expressed different amounts of the IL-5 receptor alpha (IL-5R alpha) subunit, which caused contrasting effects in response to IL-5. IL-5 supported the survival but not the anti-apoptotic activities of TF-1 cells, which have a low expression of IL-5R alpha. In contrast, IL-5 supported both the survival and the anti-apoptotic activities of JYTF-1 cells, which overexpressed IL-5R alpha compared to TF-1 cells. In this study, IL-5 stimulation increased Annexin V binding (indicative of apoptosis) in TF-1 cells and decreased apoptosis in JYTF-1 cells. The proto-oncogenes c-fos, fosB, and c-jun were not detected, whereas junB was induced by IL-5 stimulation in both types of cells. Most importantly, IL-5 significantly induced c-myc expression in JYTF-1 cells, but did not in TF-1 cells. These results are consistent with the possibility that IL-5 inhibits apoptosis in JYTF-1 cells via the upregulation of c-myc expression. ------>tmu_sno=None ------>sno=9218 ------>authors2=Yen JY ------>authors3=Lee HM ------>authors4=Huang HM ------>authors5= ------>authors6= ------>authors6_c=None ------>authors=Juan SH ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=None ------>publish_area=None ------>updateTitle=IL-5 inhibits apoptosis by upregulation of c-myc expression in human hematopoietic cells. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2005 ------>submit_flag=None ------>publish_month=None |