| Gibson FC |
------>authors3_c=None ------>paper_class1=1 ------>Impact_Factor=12.563 ------>paper_class3=2 ------>paper_class2=1 ------>vol=109 ------>confirm_bywho=seanlee ------>insert_bywho=hhchou ------>Jurnal_Rank=1.4 ------>authors4_c=None ------>comm_author= ------>patent_EDate=None ------>authors5_c=None ------>publish_day=None ------>paper_class2Letter=None ------>page2=6 ------>medlineContent= ------>unit=F0100 ------>insert_date=20040507 ------>iam=3 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN=None ------>authors_c=None ------>score=494 ------>journal_name=Circulation ------>paper_name=Innate immune recognition of invasive bacteria accerlerates atherosclerosis in apolipoprotein E-deficient mice. ------>confirm_date=20090327 ------>tch_id=086008 ------>pmid=15123526 ------>page1=2801 ------>fullAbstract=BACKGROUND: Infectious diseases have emerged as potential risk factors for cardiovascular disease (CVD). Epidemiological studies support a connection between periodontal disease, a chronic inflammatory disease of the supporting tissues of the teeth, and CVD. METHODS AND RESULTS: To directly test the connection between periodontal disease and atherosclerosis, apoE-/- mice were orally challenged with the periodontal disease pathogen Porphyromonas gingivalis or an invasion-impaired P gingivalis fimbriae-deficient mutant (FimA-). Both wild-type P gingivalis and the FimA- mutant were detected in blood and aortic arch tissue of apoE-/- mice by PCR after challenge. ApoE-/- mice challenged with wild-type P gingivalis presented with increased atherosclerotic plaque and expressed the innate immune response markers Toll-like receptor (TLR)-2 and TLR-4 in aortic tissue. Despite detection of the FimA- mutant in the blood and in aortic arch tissue, apoE-/- mice challenged with the FimA- mutant did not present with periodontal disease, upregulation of TLRs, or accelerated atherosclerosis. Furthermore, we demonstrate that immunization to control P gingivalis-elicited periodontal disease concomitantly prevents P gingivalis-accelerated atherosclerosis. CONCLUSIONS: We conclude that invasive P gingivalis accelerates atherosclerosis. ------>tmu_sno=None ------>sno=9264 ------>authors2=Hong C ------>authors3=Chou HH ------>authors4=Yumoto H ------>authors5=Chen J ------>authors6=Lien E, Wong J, Genco CA ------>authors6_c=None ------>authors=Gibson FC ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=None ------>publish_area=None ------>updateTitle=Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=22 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2004 ------>submit_flag=None ------>publish_month=None |