Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Shih YH
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------>ISSN=0020-7454
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------>journal_name=International Journal of Neuroscience
------>paper_name=GABAergic Neuron Death in the Striatum Following Kainate-induced Damage of Hippocampal Neurons:Evidence for the Role of NO in Locomotion
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------>fullAbstract=The authors examined the role of nitric oxide (NO) in the relationship between kainate-induced neuronal death and locomotion changes. Locomotion was significantly increased 1 h after kainate injection, suggesting that kainate induced NO and dopamine release. Cell death occurred in the CA1 (41%) and CA3 (54%) regions at 12 h. At 7 days, GABAergic neurons in striatum were lost, suggesting possible pyramidal neuron synapse with striatal GABAergic neurons, and pyramidal neuron damage leading to deafferentation and degeneration of striatal GABAergic neurons. Pre-administration of Nw-nitro-L-arginine-methyl-ester or 7-nitroindazole reduced these effects. These results indicate that NO may modulate kainate-induced neuronal death and locomotion.
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------>authors2=Lee AW
------>authors3=Huang YH
------>authors4=Ko MH
------>authors5=Fu YS
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------>authors=Shih YH
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------>updateTitle=GABAergic neuron death in the striatum following kainate-induced damage of hippocampal neurons: evidence for the role of NO in locomotion.
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------>publish_year=2004
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z