| Chou YH |
------>authors3_c=None ------>paper_class1=1 ------>Impact_Factor=None ------>paper_class3=2 ------>paper_class2=1 ------>vol=37 ------>confirm_bywho=yangyuan ------>insert_bywho=ycliang ------>Jurnal_Rank=None ------>authors4_c=None ------>comm_author=1 ------>patent_EDate=None ------>authors5_c=None ------>publish_day=None ------>paper_class2Letter=None ------>page2=615 ------>medlineContent= ------>unit=E0300 ------>insert_date=20041013 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN=None ------>authors_c=None ------>score=500 ------>journal_name=Inter J Biochem Cell Biol. ------>paper_name=The possible role of heat shock factor-1 in the negative regulation of heme oxygenase-1. ------>confirm_date=20051219 ------>tch_id=089135 ------>pmid=15618017 ------>page1=604 ------>fullAbstract=We examined a possible role for heat shock factor-1 (HSF-1) in the negative regulation of HO-1 gene expression in human Hep3B hepatoma cells responding to stimulation with 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) and arsenite. Overexpression of HSF-1 and heat-shock experiments indicated that HSF-1 repressed the 15d-PGJ2-and arsenite-induced HO-1 gene expression through directly binding to the consensus heat shock element (HSE) of the HO-1 gene promoter. In addition, point mutations at specific HSE sequences of the HO-1 promoter-driven luciferase plasmid (pGL2/hHO3.2-Luc) abolished the heat shock- and HSF-1-mediated repression of reporter activity. Overall, it is possible that HSF-1 negatively regulates HO-1 gene expression, and that the HSE present in the -389 to -362 region mediates HSF-1-induced repression of human HO-1 gene expression. ------>tmu_sno=None ------>sno=9829 ------>authors2=Ho FM ------>authors3=Liu DZ ------>authors4=Lin SY ------>authors5=Tsai LH ------>authors6=Chen CH, Ho YS, Hung LF and Liang YC ------>authors6_c=None ------>authors=Chou YH ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=None ------>publish_area=None ------>updateTitle=The possible role of heat shock factor-1 in the negative regulation of heme oxygenase-1. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2005 ------>submit_flag=None ------>publish_month=None |